HORDB

ID: hor002803
Uniprot ID: P20481
Protein name: Buccalin gene-predicted acidic peptide B
Gene name: NA
Organism: Aplysia californica (California sea hare)
Family: NA
Source: animal
Expression: Cholinergic motor neuron B15 innervating buccal muscles in Aplysia.
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: SSSEQEEEDVRQVE
Length: 14(479-492)
Propeptide: MAHHRGHRHILLYVSLALSLGLALAEDATDPSDDTGSFDDVEAVSEEADLDPYSMSQELNKRPNVDPYSYLPSVGKRAFDHYGFTGGLGKRKIDHFGFVGGLGKRQIDPLGFSGGIGKRYDSFAYSAGLGKRGMDSLAFSGGLGKRGMDSLAFSGGLGKRGMDSLAFSGGLGKRGMDSLAFSGGLGKRGMDSLAFSGGLGKRGMDSLAFSGGLGKRGMDSFTFAPGLGKRGMDSLAFAGGLGKRMDGFAFAPGLG
Signal peptide: MAHHRGHRHILLYVSLALSLGLALA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Acting presynaptically on nerve terminals to inhibit acetylcholine release
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P41539-F1.pdb

hor002803_AF2.pdb

hor002803_ESM.pdb

Mass:	188267	Formula:	C64H103N19O32
Absent amino acids:	ACFGHIKLMNPTWY	Common amino acids:	E
pI:	3.59	Basic residues:	1
Polar residues:	3	Hydrophobic residues:	2
Hydrophobicity:	-189.29	Boman Index:	-7089
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	41.43
Instability Index:	14677.14	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 8101868
Title: The Buccalin-Related Neuropeptides: Isolation and Characterization of an Aplysia cDNA Clone Encoding a Family of Peptide Cotransmitters